PATINA Press Release

Alliance Foundation Trials Phase III PATINA Study Results Published in the New England Journal of Medicine

Alliance Foundation Trials, LLC (AFT) announced the publication of the pivotal phase III PATINA study (AFT-38) in the New England Journal of Medicine (NEJM), marking a major milestone for patients with hormone receptor–positive (HR+), human epidermal growth factor receptor 2–positive (HER2+) advanced breast cancer (ABC). The study’s results demonstrate that the addition of the CDK4/6 inhibitor palbociclib to standard first-line maintenance therapy significantly prolongs progression-free survival (PFS) by more than 15 months compared with standard therapy alone.

Read more on our News page, linked here.

Hero Baner

AFT Seeking to Reduce the Impact of Cancer

Cancer clinical trials working closely with pharmaceuticals, collaborators and the Alliance scientific investigators & institutional member network.

About Us

About Us

Alliance Foundation Trials, LLC (AFT) is a research organization that develops and conducts cancer clinical trials, working closely with pharmaceutical partners, research collaborators and the Alliance for Clinical Trials in Oncology scientific investigators and institutional member network. AFT seeks to fulfill the vision of the Alliance for Clinical Trials in Oncology to reduce the impact of cancer on people by uniting a broad community of scientists and clinicians from many disciplines committed to discovering, validating and disseminating effective strategies for the prevention and treatment of cancer.

Established in 2014 as a limited liability corporation, AFT is managed by the Alliance for Clinical Trials in Oncology Foundation, which is its sole member. The AFT operational structure and funding sources are separate from the Alliance clinical trials program funded by the National Cancer Institute (NCI).

Evanthia Galanis, MD, DSc | President

Evanthia Galanis, MD, DSc, is President of Alliance Foundation Trials (AFT) LLC and Group Chair of the Alliance for Clinical Trials in Oncology, where she provides scientific and strategic leadership for one of the nation’s largest oncology clinical trials networks. She is the Sandra J. Schulze Professor of Novel Therapeutics and Professor of Oncology at Mayo Clinic, with joint appointments in the Division of Medical Oncology and the Department of Molecular Medicine.

An internationally recognized leader in neuro-oncology, Dr. Galanis has led numerous cooperative group phase II and randomized clinical trials and maintains a strong research focus on innovative trial design and clinically meaningful endpoints in neuro-oncology.

Olwen Hahn, MD | Vice President

Olwen Hahn, MD, serves as Vice President of Alliance Foundation Trials (AFT) LLC and contributes clinical and operational leadership to advance high-quality oncology research. She is an Associate Professor of Medicine at the University of Chicago and serves as Director and Principal Investigator of the Alliance Central Protocol Operations Program, where she oversees the clinical operations of a large national portfolio of oncology studies.

A nationally recognized breast cancer specialist, Dr. Hahn’s clinical practice focuses on the diagnosis and treatment of all forms of breast cancer, integrating standard therapies with innovative clinical trials to deliver personalized patient care.

Kimberly Kerstann, PhD – Secretary

Kimberly Kerstann, PhD, serves as Secretary of Alliance Foundation Trials (AFT) LLC and is Chief Operating Officer of the Alliance for Clinical Trials in Oncology. She brings extensive experience in scientific research, clinical trials administration, and organizational leadership, supporting AFT’s mission through strong governance, operational excellence, and regulatory oversight.

Dr. Kerstann is committed to aligning scientific innovation with effective operational strategy to strengthen research infrastructure and support the successful execution of complex, multi-institutional clinical trials.

Drew Gollerkeri, MBA | Treasurer

Drew Gollerkeri, MBA, serves as Treasurer of Alliance Foundation Trials (AFT) LLC, providing financial leadership and strategic oversight in support of the organization’s clinical research mission. He brings experience in financial management, operational strategy, and organizational governance within complex healthcare and research environments.

In his role, Mr. Gollerkeri oversees budgeting, financial planning, and fiscal stewardship to ensure responsible resource allocation, long-term sustainability, and alignment with AFT’s scientific and operational priorities.

David Kozono, MD, PhD | Group Vice Chair and Principal Investigator

David Kozono, MD, PhD, serves as Group Vice Chair and Principal Investigator of the Alliance for Clinical Trials in Oncology and supports the overall advancement of Alliance Foundation Trials (AFT) LLC and its mission to develop and execute practice-changing oncology studies. He is an Associate Professor of Radiation Oncology at Harvard Medical School and Director of Thoracic Radiation Oncology at the Dana-Farber/Brigham and Women’s Cancer Center.

Dr. Kozono specializes in the treatment of thoracic malignancies, including lung cancer, and is committed to translating scientific discoveries into the design and conduct of innovative clinical trials with strong translational medicine objectives. His work reflects a dedication to integrating rigorous science with clinical care to improve outcomes for patients with cancer. 

Executive Officers

  • Lyudmila Bazhenova, MD | University of California San Diego

  • Stephanie Berg, DO | Dana-Farber Cancer Institute

     

  • Selina Chow, MD | Alliance for Clinical Trials in Oncology
     

  • Shira Dinner, MD | Northwestern University
     

  • Beth Helmink, MD, PhD | University of Texas MD Anderson Cancer Center

  • Priya Kumthekar, MD | Northwestern University

     

  • Filipa Lynce, MD | Dana-Farber Cancer Institute
     

  • Otto Metzger, MD | Dana-Farber Cancer Institute
     

  • Ardaman Shergill, MD | University of Chicago

  • Gloria Sura, MD | University of Texas MD Anderson Cancer Center

  • Anna Weiss, MD | University of Rochester Medical Center

Trials

Trials

AFT offers clinical trial investigators, pharmaceutical partners and the Alliance for Clinical Trials in Oncology institutional member network collaborative opportunities to develop and conduct trials, in addition to NCI-funded initiatives. This expands access and trial design options. AFT studies are developed by the Alliance scientific committees and are integrated into scientific goals of the committees.

Sites eligible to participate in AFT trials are members of the Alliance for Clinical Trials in Oncology network in good standing. AFT determines site-protocol matches based on previous site performance, accrual reports and results from its feasibility process. AFT invites sites that meet these criteria to participate in trials.  

Site Identification Criteria

  • Overall good standing as Alliance member
  • AFT conducts feasibility process to assess site’s capability to conduct trial based on specific protocol requirements
  • AFT reviews previous site performance and accrual reports to determine site selection in general
  • AFT invites site to participate

There are several differences between AFT Trials and Alliance Trials.  The areas of difference are noted below.  

AFT accrual credits are applied only after the network has met their requirements for Alliance Membership.  Click here for more information.

Differences Between AFT and Alliance Trials

  • Study Selection and Development
  • Site Selection
  • Operations Systems and Partners
  • Contracts and Funding
  • Alliance Membership Accrual
  • Operations Systems and Partners

Study List/Links

 

 

AFT Studies

 

All studies can be viewed in more detail through the NIH's online database at ClinicalTrials.gov. These listings include the most up-to-date information about the studies as well as their results. Select from the following disease types and other conditions for a list of existing AFT trials that meet the criteria.

 

Types of Cancer Other Conditions
   
Breast Autoimmune 
Carcinoma Venous Thromboembolism
Endometrial Metastatic Cancers
Lymphoma  
Myeloma  
Prostate  
Respiratory  

 

 

Additionally, a full list of all open and closed AFT trials is available below. For information about other clinical trials, please visit ClinicalTrials.gov.

Study Table

 

 

Study Number ClinicalTrials.gov ID Brief Title Acronym Disease/Condition Enrollment Enrollment Type Status

 

Contact Us

Contact Us

AFT Information info@alliancefoundationtrials.org For site participation and general information
AFT Tech Support Help Desk techsupport@alliancefoundationtrials.org For technical support & systems access
AFT Careers Please see careers link in the menu below.
Alliance Foundation Trials, LLC 101 Federal St., Suite 1900 Boston, MA 02110