AFT Seeking to Reduce the Impact of Cancer Cancer clinical trials working closely with pharmaceuticals, collaborators and the ACTO scientific investigators & institutional member network.

About Us

Alliance Foundation Trials, LLC (AFT) is a research organization that develops and conducts cancer clinical trials, working closely with pharmaceutical partners, research collaborators and the Alliance for Clinical Trials in Oncology (ACTO) scientific investigators and institutional member network. AFT seeks to fulfill the vision of the Alliance for Clinical Trials in Oncology to reduce the impact of cancer on people by uniting a broad community of scientists and clinicians from many disciplines committed to discovering, validating and disseminating effective strategies for the prevention and treatment of cancer.

Established in 2014 as a limited liability corporation, AFT is managed by the Alliance for Clinical Trials in Oncology Foundation, which is its sole member. The AFT operational structure and funding sources are separate from the Alliance clinical trials program funded by the National Cancer Institute (NCI).

Monica M. Bertagnolli, MD | President  

An internationally renowned surgeon-scientist, Monica M. Bertagnolli, MD, is Chief of the Division of Surgical Oncology at Brigham and Women's Hospital and Professor of Surgery at Harvard Medical School. She is also Group Chair of the Alliance for Clinical Trials in Oncology and President of the Alliance for Clinical Trials in Oncology Foundation.

Her innovative research has focused on gastrointestinal tumor biology, striving to develop patient-specific cancer prevention and treatment strategies. Dr. Bertagnolli specifically investigates the adenomatous polyposis coli (APC) gene function and its regulation of colorectal cancer. Her clinical practice is dedicated to patients with germline APC gene mutations.

Suzanne George, MD | Vice President  

A leading medical oncologist and expert in sarcoma management and clinical investigation, Suzanne George, MD, is Clinical Director at the Center for Sarcoma and Bone Oncology at Dana-Farber Cancer Institute and Associate Professor of Medicine at Harvard Medical School. She is also Group Vice-Chair of the Alliance for Clinical Trials in Oncology.

Her interests have led her to develop and lead multiple clinical trials evaluating novel therapeutics for patients with advanced sarcomas and GIST, much of which has impacted the standard of care for patients with these diseases. She has also led one of the largest clinical multidisciplinary sarcoma teams, bringing together various specialists with the goal of optimizing patient care and outcomes.

Gini F. Fleming, MD | Chief Scientific Officer  

Gini F. Fleming, MD, is Professor of Medicine, Director of the Medical Oncology Breast Program and Medical Oncology Director of Gynecologic Oncology at the University of Chicago. An expert in breast and gynecological cancers, she is also Principal Investigator and Director of the Central Protocol Operations Program at the Alliance for Clinical Trials in Oncology.

Her recent research examines novel therapeutics in breast, ovarian, and endometrial cancers. Dr. Fleming has authored and co-authored more than 100 articles for a variety of medical journals, in addition to a number of textbook chapters.

Executive Officers

  • Linda Sluman, MD | U Chicago Comprehensive Cancer Center
  • David Kozono, MD, PhD | Dana-Farber Cancer Institute
  • Otto Metzger, MD | Dana-Farber Cancer Institute
  • Priya Kumthekar, MD | Northwestern University
  • Shira Dinner, MD | Northwestern University


Get the latest from AFT
28 ago 2017 - 00:00:00
AFT Launches PALLAS Trial Alliance Foundation Trials and Austrian Breast & Colorectal Cancer Study Group Open Largest Global Phase 3 Trial of Targeted Therapy, IBRANCE® (palbociclib), for Patients with Hormone Receptor-Positive Early Breast Cancer Read more
01 jun 2017 - 00:00:00
New PALLAS Trial Website There is now a new PALLAS Website! Read more
19 ene 2017 - 00:00:00
AFT Portal Updates AFT Operations has been working to create a better Portal experience for all of our users. In the upcoming weeks there will be updates to the system to enhance the User Experience! The AFT Portal will be experiencing planned interruptions Wednesday January 18 at 1800 EST as well as Thursday January 19th at 1800 EST. We apologize for any inconvenience. Read more


AFT offers clinical trial investigators, pharmaceutical partners and the Alliance for Clinical Trials in Oncology institutional member network collaborative opportunities to develop and conduct trials, in addition to NCI-funded initiatives. This expands access and trial design options. AFT studies are developed by the Alliance scientific committees and are integrated into scientific goals of the committees.

Sites eligible to participate in AFT trials are members of the Alliance for Clinical Trials in Oncology network in good standing. AFT determines site-protocol matches based on previous site performance, accrual reports and results from its feasibility process. AFT invites sites that meet these criteria to participate in trials.  

Site Identification Criteria

  • Overall good standing as Alliance member
  • AFT conducts feasibility process to assess site’s capability to conduct trial based on specific protocol requirements
  • AFT reviews previous site performance and accrual reports to determine site selection in general
  • AFT invites site to participate

There are several differences between AFT Trials and Alliance Trials.  The areas of difference are noted below.  

AFT accrual credits are applied only after the network has met their requirements for Alliance Membership.  Click here for more information.

Differences Between AFT and Alliance Trials

  • Study Selection and Development
  • Site Selection
  • Operations Systems and Partners
  • Contracts and Funding
  • Alliance Membership Accrual
  • Operations Systems and Partners

Contact Us

AFT Information For site participation and general information
AFT Tech Support Help Desk For technical support & systems access
AFT Careers For information on open positions
Alliance Foundation Trials, LLC 221 Longwood Ave., Room 108 Boston, MA 02115